Ecological and environmentally friendly mouse control methods cause minimal damage to other species and ecosystems as a means of controlling rodent populations. The basis for this is Integrated Pest Management, which focuses on the processes of prevention, monitoring, and a combination of the use of control measures. Improving sanitation through removal of food and water sources, sealing the buildings to prevent entry, and using traps in preference to toxic baits so that mice can be captured without harming other wildlife; habitat modification is crucial because cleanliness of outdoor places and clutter reduction and landscaping away from nesting sites could discourage rodents. This, coupled with natural repellents such as peppermint oil and ultrasonic deterrents, will make a place unattractive for mice. In case chemical methods are applied, the choice of targeted, least toxic rodenticides and strict follow-up on application guidelines are applied to minimize the unintended outcomes. Education and community input are also essential, with awareness and proactive behaviors having the potential to improve sustainable practices. By focusing on these methods, we would be able to have successful rodent control and keep the ecological balance provided with a healthier environment.