Inhaling molecular hydrogen (H2) reduces oxidative stress and inflammation in the body. It also promotes cognitive function, enhances athletic performance, and helps the body detoxify.
Molecular hydrogen gas penetrates cell membranes to neutralize free radicals, which are the cause of oxidative stress and many chronic diseases. It can also inhibit the growth of cancer cells. 水素吸入器の購入はコチラ
Anti-Inflammatory
The molecular hydrogen molecule is able to penetrate deep into the cells of living organisms, inhibiting their signaling pathways and inducing anti-inflammatory responses. This prevents the overproduction of pro-inflammatory cytokines and promotes the production of antioxidant enzymes. This reduces the oxidative stress and inflammation in the body, protecting against diseases such as fibromyalgia, inflammatory bowel disease, arthritis, and asthma.
Hydrogen inhalation significantly improves exercise performance in healthy people. It has ergogenic properties that increase strength and running efficiency, resulting in improved athletic abilities. The beneficial effects of hydrogen inhalation appear to be mediated by its ability to target the Nrf2 pathway, a master antioxidant regulation pathway. Many pharmaceutical companies are currently developing drugs that target the Nrf2 pathway in order to combat neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease.
Molecular hydrogen can attenuate inflammatory reactions caused by LPS, sepsis, and other pathogenic factors in animal experiments. It significantly decreases the severity of lung injury in ALI induced by seawater instillation, protects against oleic acid-induced pulmonary fibrosis, and attenuates the development of interstitial fibrosis in rheumatoid arthritis-associated interstitial fibrosis (Terasaki et al., 2019a).
It also alleviates pulmonary fibrosis in rats with LPS-induced ALI by inhibiting the activation of NF-kB and p38MAPK in lung tissue. This leads to the downregulation of inflammatory mediators and suppression of apoptosis, which significantly improves oxygenation and gas exchange.
In addition to its innate immune-stimulatory effect, molecular hydrogen has strong anti-cancer effects. It protects against oxidative stress and inflammation, which are common side effects of conventional anti-cancer therapies, such as chemotherapy and radiation therapy. It also prevents the overproduction of inflammatory cytokines by the cancer cells, thereby reducing tumor growth and inhibiting cell metastasis. In a gefitinib-treated cellular model, hydrogen attenuates the inflammatory response and apoptosis and increases the expression of the anti-inflammatory cytokine IL-10. These results suggest that hydrogen may enhance the effectiveness of anti-cancer therapy by attenuating oxidative stress and inflammation, and enhancing apoptosis and the anti-proliferative effect of gefitinib.
Antioxidant
Molecular hydrogen is a natural antioxidant and anti-inflammatory, and it can be administered by a variety of methods such as inhalation (inhaler), drinking hydrogen-rich water or using a hydrogen bath. This unique property of molecular hydrogen makes it a safe and effective anti-aging therapy because it can reach the cellular level, where it neutralizes the harmful free radicals that cause damage.
Inhaling hydrogen gas increases the production of adenosine triphosphate (ATP), a molecule that fuels the cells, and it reduces the oxidative stress that can lead to apoptosis. It can also increase the sensitivity of the mitochondria to insulin, which leads to improved glucose control and lower blood sugar levels.
A growing body of evidence suggests that molecular hydrogen has broad biological effects on a wide range of disorders, including ischemia-reperfusion injury, inflammation, autophagy, programmed cell death and the aging process. It also has direct protective effects on the lungs and lung tissues. This protective effect is mediated by multiple mechanisms, including attenuation of pro-inflammatory cytokines in the lungs, a reduction of oxygen radicals and nitric oxide, activation of the Nrf2 and HO-1 pathways, improved gas exchange, lowered inflammatory responses, and decreased apoptosis.
In a sepsis-like animal model of acute lung injury, inhalation of 2% hydrogen gas protected the lungs from necrosis and inflammatory responses. It also reduced the expression of apoptosis-promoting genes and attenuated mitochondrial dysfunction and oxidative stress. In human studies, hydrogen inhalation has been shown to enhance critical care medicine and chronic diseases such as rheumatoid arthritis and neurodegenerative disease1,2.
A study on patients with COPD showed that 2.4% hydrogen gas inhaled for 45 minutes significantly reduced the synthesis of inflammatory factors and increased oxidative metabolism in the lungs. It also inhibited the decline in the aryl hydrocarbon receptor (AhR) induced by concentrated ambient particulate matter and alleviated the lung damage resulting from AhR deficiency in COPD patients (Wang ST et al, 2020). Inhaling molecular hydrogen can help you achieve a state of "restitutio ad integrum" or whole-body healing, which can help prevent chronic disease and improve your overall health.
Anti-Cancer
Hydrogen gas inhalation corrects oxidative stress and suppresses cell growth. It also enhances mitochondrial function and prevents cellular aging. In addition, it reduces the expression of genes associated with inflammatory and cancerous processes. This may be why it is so effective against various diseases associated with oxidative stress, such as neurodegeneration, cancer, and cardiovascular disease.
Hydrogen therapy may even be helpful in the prevention of aging-related disorders such as Parkinson's disease and Alzheimer's disease. Inhaling hydrogen has been shown to alleviate the symptoms of these conditions by inhibiting the activation of NF-kB and COX-2. Hydrogen has also been found to inhibit the synthesis of proinflammatory cytokines and chemokines, while promoting the synthesis of anti-inflammatory proteins. It is believed that the anti-inflammatory effects of hydrogen are responsible for its beneficial effects on aging.
Inhaling hydrogen gas significantly inhibits the growth of cancer cells in culture and in vivo, including melanoma and ovarian cancer. It has also been found to induce tumor cell apoptosis and attenuate the migration and invasion of cancer cells. In a clinical trial, hydrogen gas significantly reduced the incidence of colorectal cancer and improved the patient's prognosis.
Molecular hydrogen also has the ability to alleviate the adverse side effects of conventional anti-cancer treatments. It reduces oxidative stress and inflammation in cultured cells and in mice exposed to radiation. It also attenuates the naphthalene-induced ALI in gefitinib-treated mice, and does not impair the antitumor effects of the drug (Qian et al., 2010; Qiu et al., 2020).
Furthermore, it suppresses inflammatory responses to the gastrointestinal virus (EV-63), attenuates LPS-induced pulmonary inflammation, and decreases lung MPO activity. It is also known to inhibit p38MAPK-dependent ROS generation and suppresses the production of inflammatory cytokines and chemokines. These results suggest that inhaling H2 might be a novel strategy for the treatment of lung injury caused by EV-63 and other viruses. It could also be useful in the improvement of athletic performance by enhancing the recovery from exercise-induced oxidative stress, and by improving running efficiency. It has been reported that inhaling hydrogen for a short period of time increases the torso strength and running speed of healthy people in a laboratory test.
Anti-Aging
Molecular hydrogen has anti-aging effects and can reduce symptoms of diseases related to aging. It prevents oxidation of proteins and fats, suppresses inflammatory cytokines and enhances glucose uptake into muscles. It also helps to improve blood sugar and lipid metabolism and reduces fat retention. The molecular hydrogen has an effect on the Nrf2 signaling pathway, which is a master regulator of antioxidant enzymes and proteasomes and has a role in nutrient sensing, mitochondrial function, telomere maintenance, autophagy, and cellular senescence. This means that additional regular intake of molecular hydrogen by drinking hydrogen water and inhalation can prevent the onset of neurodegenerative disease, slow the aging process and keep you healthy.
Hydrogen is a tasteless, odorless gas that has demonstrated various biological and therapeutic effects for a wide range of acute and chronic diseases, such as ischemia-reperfusion injury, inflammation, metabolic syndromes, and cancers1,2. Hydrogen is non-toxic at high concentrations and can cross the blood-brain barrier to protect neurons from oxidative stress. Furthermore, it has a unique property that distinguishes it from other antioxidants: it can dismutate oxygen radicals without decomposition into other molecules, thus maintaining its protective effect.
A study has shown that inhaling hydrogen for a short period of time can improve healthy people’s torso strength and running efficiency, while also attenuating the decline in peak power output during repetitive sprint exercise. This is probably because hydrogen acts as a redox adaptogen and potentiates beneficial exercise-associated low-grade inflammation and attenuates harmful exercise-associated high-grade inflammation and oxidative damage to muscle cells.
Another clinical trial found that inhaling hydrogen for 30 days improved type 2 diabetics’ oxidative stress, insulin resistance and blood glucose levels. This was due to hydrogen’s ability to reduce oxidation of proteins and fats, as well as its positive impact on the liver’s glucose production and regulation.
A simple experiment with apples can illustrate the effect of molecular hydrogen. Place a slice in a glass of water, another in plain water and the third in a bottle of hydrogen-enriched water. The slice exposed to the normal air oxidizes the fastest, but the slice in the hydrogen water remains the freshest.