General Aim of Preparation of Paracetamol:
Synthesis of paracetamol. In this section, the preparation of paracetamol is introduced within the broader context of organic synthesis.
Method of Preparation of Paracetamol:
Paracetamol can be mainly prepared through addition-elimination reaction; where an aminol group of p-aminophenol reacts with the carboxylic group of acetic anhydride to form paracetamol and acetic acid. This reaction is catalyzed by the presence of concentrated acids (as sulfuric acid) to force the reaction forward, preventing it from going backward. This reflects the fundamental approach used in the laboratory preparation of paracetamol.